ea0028p190 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012
Beale Kylie
, Gardiner James
, Bewick Gavin
, Hostomska Klara
, Patel Neekhil
, Hussain Syed
, Ebling Francis
, Jethwa Preeti
, Prosser Haydn
, Ghatei Mohammad
, Bloom Stephen
, Dhillo Waljit
Prokineticin 2 (PK2) is a neuropeptide expressed in hypothalamic nuclei involved in the regulation of energy homeostasis, and has been shown to acutely reduce food intake in rodents. PK2 binds to and activates two G protein-coupled receptors, the PK receptor 1 (PKR1) and the PK receptor 2 (PKR2). We aimed to determine the sites and receptors which mediate the anorectic effects of peripherally administered PK2 within the CNS. We investigated neuronal activity in the hypothalamu...